Maybe. On my car I install on of those "600hp/100mpg" black box... well, 10 hp maybe. I did that with a ram air straight in the stock air box with a K&N. My car is rated 26/30 and I get about 35mpg if I stay right below 3000 rpm (70 mph)With a more efficient and better flowing system, shouldn't you also get more fuel economy, as long as you don't hammer on it?
On my bike I have a 16/38 (80 mph @ 6000rpm) and if I go 70-90 mph I average 50 mpg. The bike is bone stock as of right now. I'm in the process of getting my R6 headers done. Just had to order a collector (2-1) for it. So I can weld it on the headers without bending it. I'm aiming for a Supertrapp muffler. Not the greatest but I like the fact that I will be able to tune it a bit. Either for performance, or noise. One thing sure, the exhaust will stay underneath.